منابع مشابه
The Potential Effect of Glycyrrhiza Glabra on Early Step of Influenza Virus Replication
Background and Aims: The emergence of drug-resistant influenza viruses has become a serious threat for human and animal populations. Glycyrrhiza glabra (Gg) is a traditional medicine clinically used for the treatment of viral respiratory infection symptoms in most countries. We evaluated the effects of the herb on influenza virus replication in human lung cultured cells (A549) following the det...
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The correct processing of Okazaki fragments during lagging-strand DNA replication has a vital role in maintaining genome integrity. Recent findings suggest that, in eukaryotes, the processing of Okazaki fragments occurs by a two-step mechanism governed by the single-stranded DNA binding factor RPA.
متن کاملRegulation of eukaryotic DNA replication at the initiation step.
The studies of cell growth and division have remained at the centre of biomedical research for more than 100 years. The combination of genetic, biochemical, molecular and cell biological techniques recently yielded a burst in what is known of the molecular control of cell growth processes. The initiation of DNA replication is crucial for the stability of the genetic information of a cell. Two f...
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E ukaryotic DNA replication is strictly coupled to cell cycle regulation, with the initiation step sensing and integrating signals from the cell cycle machinery. Replication initiates from so-called origin sequences on chromosomal DNA, which in budding yeast are bound by origin recognition complex (ORC) proteins throughout the cell cycle. In the G1 phase, hexameric Mcm2-7 helicase core complexe...
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The opening of the Y-fork the first step of DNA replication is shown to be a critical phenomenon under an external force at one of its ends. From the results of an equivalent delocalization in a nonhermitian quantum-mechanics problem we show the different scaling behavior of unzipping and melting. The resultant long-range critical features within the unzipped part of Y might play a role in the ...
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ژورنال
عنوان ژورنال: Nature
سال: 1994
ISSN: 0028-0836,1476-4687
DOI: 10.1038/372626c0